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Discover Curapath's cutting-edge offerings in our catalog. Explore our LNP and PNP components, as well as our polymer conjugates, all designed to advance drug delivery. Enhance your research and development with our high-quality products. Download our catalog now and take the first step towards innovative solutions.
Advanced Polymer & Lipid Solutions for Non-Viral Drug Delivery
PEG-free excipients, transfection reagents, and polymer platforms for next-generation therapeutics
Polymer-based transfection reagents designed as safe, scalable alternatives to viral vectors for DNA delivery and in-vivo cell engineering.
Target Applications
- DNA vaccines
- In-vivo CAR-T and immune cell programming
- Gene delivery for research and clinical development
Key performance attributes
- High DNA transfection efficiency
- Reduced cytotoxicity
- Low innate immune activation → enables repeat dosing
- Biodegradable polymer architectures
- Targetable and tunable systems
Technology platforms
STAR polymers
Patented high-performance transfection reagents for DNA vaccines and in-vivo CAR-T, with targetable architectures.
Nanoparticle stabilizers & shielding polymers
- PSar shielding polymers – toxicity-reduction agents when combined with polycations for in-vivo use
- PEG-PLE and other PEG Copolymers as shielding polymers – available in GMP grade.
Tunable transfection polymers
- PBAEs
- Modified poly-amino acids (PLys, PLO, PArg)
- PAMAM dendrimers
Polymer technologies designed to replace PEG in Nanoparticle Formulations
Advantages vs PEG
- Low immunogenicity and low reactogenicity
- Avoids anti-PEG antibody formation
- Reduced bioaccumulation
- Slower blood clearance → enables re-administration
Target applications
- RNA vaccines
- Gene therapy
- Gene editing
- Oncology
- Extrahepatic and inhaled delivery
Technology platforms
PSar
Versatile, biodegradable, and targetable shielding polymer.
VitE-PSar
Patented PSar derivative with improved stability in solution
PGA-diol
Patented biodegradable shielding lipid with high transfection efficiency, designed for:
- Freeze-dried LNPs
- Long-term stability
- Inhalation delivery
pBetaines
Patented zwitterionic, biodegradable shielding lipids.
PoAx platform
Tunable polymer platform enabling customized circulation and shielding profiles.
Target applications
- Monoclonal antibodies
- Proteins and peptides
- Hydrophobic small molecules
- Injectable and topical formulations
Technology platforms
Oleyl-PSar
Patented alternative to polysorbates offering:
- Improved oxidative stability
- Enhanced solubilization performance
- Ideal for second-generation reformulation of polysorbate-based drugs
PSarylation
Next-generation polymer–biologic conjugation technology:
- Biodegradable alternative to 40 kDa PEGylation
- Tunable polymer chain length
- Improved PK and safety profile
Biodegradable polymer backbones designed to improve solubility, stability, circulation time, and targeting, particularly for challenging or highly potent payloads.
Key benefits
- Improved pharmacokinetics
- Reduced off-target toxicity
- Targetable architectures
- Suitable for HPAPI conjugation
Polymer Platforms
PGA
Biodegradable alternative to PEG and HPMA for HPAPI conjugation.
PLys, PLO (ornithine) & copolymers
Tunable polymer backbones for controlled drug conjugation and release.
Polymer systems for surface functionalization and medical device coatings.
Polymer platforms
- PLL (Poly-L-lysine)
- PAA family
- Polyhistidine
- Polyornithine
- Polyarginine
- Tunable copolymers (hydrophobic domains, amphiphiles, bola-amphiphiles)
Frequently asked Questions
Curapath is a European Contract Development and Manufacturing Organization (CDMO) specialized in lipid- and polymer-based delivery systems. We support biotech and pharmaceutical companies from early development through GMP-ready manufacturing.
Our core expertise includes polymer and lipid excipients, lipid nanoparticles (LNPs), polymer nanoparticles (PNPs), polymer–drug conjugates, and coating polymers.
The catalog includes polymer- and lipid-based excipients for non-viral drug delivery, including transfection reagents, PEG alternatives,shielding lipids for LNPs, solubilizing polymers, polymer–drug conjugate backbones, and polycationic polymers for medical device applications.
These materials support RNA, DNA, proteins, peptides, and small molecules across vaccines, gene therapy, gene editing, oncology, and biologics formulation.
Materials are available across different quality grades,depending on the product and development stage:
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Research-grade materials for early feasibility studies
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GMP-compatible or GMP-grade materials for clinical andcommercial programs
Availability of GMP grade depends on the specific polymer orlipid and can be discussed on a case-by-case basis.
Yes. Wherever possible, materials are designed and manufactured with scalability and reproducibility in mind.
Our development approach prioritizes:
- Transferability between scales
- Batch-to-batch consistency
- Alignment with regulatory expectations
This supports a smoother transition from early development to clinical manufacturing.
Yes. Our PEG alternatives are specifically designed to overcomeknown PEG limitations, including:
- Reduced immunogenicity
- Avoidance of anti-PEG antibody formation
- Lower bioaccumulation
- Improved potential for repeat administration
Suitability depends on the application and formulation context.
Yes. In addition to off-the-shelf catalog materials, weoffer custom synthesis and bespoke polymer development services.
This includes:
- Design of new polymer architectures
- Adaptation of existing platforms to specific needs
- Custom functionalization or conjugation strategies
- Scale-up and transfer to GMP manufacturing when required
Custom projects are developed in close collaboration to ensure technical feasibility and regulatory alignment.
For custom synthesis projects please contact-us
Yes, several platforms in our catalog are designed to support targeted delivery strategies across a range of therapeutic modalities, including nanoparticles engineered for extrahepatic and cell-specific delivery. These strategies include both passive and active targeting mechanisms that can be tailored to your program goals.
We have recently integrated the CliCr® bioconjugation technology into our portfolio via a co-exclusive agreement with Cristal Therapeutics. CliCr® is a site-specific, stable, and scalable bioconjugation platform that enables precise attachment of biomolecules to polymeric and lipid nanoparticles (LNPs), greatly enhancing targeting capabilities to difficult-to-reach sites such as pulmonary tissue, brain, and T cells for in-vivo applications. This expansion of our targeting arsenal strengthens our ability to design next-generation targeted drug delivery systems for nucleic acids and other biologics.
Targeting strategies and platform suitability depend on the therapeutic modality and biological context of your program.
You can contact us directly through the catalog inquiry form to:
- Request samples
- Discuss quantities and grades
- Explore custom synthesis options
- Initiate technical or regulatory discussions
Each request is reviewed to ensure the most suitablesolution is proposed.
Also you can find different formats of our products in our distributors pages:
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Contact Us, and we can discuss your specific therapeutic program and how Curapath can help build the right solution to advance your unique drug.
